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Medically Reviewed

What is Antabuse, and How Does It Work?

- 6 sections

Medically Verified: October 27, 2024

All of the information on this page has been reviewed and verified by a certified addiction professional.

When it comes to overcoming alcohol dependence, many people need much more than just willpower—sometimes, medical support can make all the difference.

That’s where Antabuse comes in, but what is Antabuse?

It’s a medication specifically to help people struggling with alcohol addiction by creating a strong physical deterrent to drinking. Understanding how Antabuse works can be an important step in finding the right recovery approach.

At Mandala Healing Center, we know every journey to sobriety is unique. We combine medical treatment options like Antabuse with compassionate, holistic care to support individuals throughout each step of the process. Whether you’re just beginning your recovery or you’re looking for additional support, we’re here to help you explore how Antabuse could be part of your path to a healthier, alcohol-free life.

What Is Antabuse?

Antabuse, also known by the generic name disulfiram, is a prescription medicine used for decades to help people with alcohol dependence.

Disulfiram works by causing a strong, negative reaction if you drink alcohol while taking it, making alcohol consumption extremely unpleasant.

Here’s how it works: when you drink alcohol, your body naturally breaks it down into something called acetaldehyde. Normally, this substance is broken down further, and your body eliminates it. However, disulfiram blocks the process, allowing acetaldehyde to build up, leading to symptoms like nausea, vomiting, headaches and flushing. The idea of the disulfiram alcohol reaction is to create a deterrent strong enough that it keeps you from drinking altogether.

Approved by the FDA for the treatment of alcohol addiction back in 1951, disulfiram has a long history of helping individuals maintain sobriety. It’s not a cure for alcoholism, but it can be a helpful tool when blended with counseling, therapy and support programs like what we offer at our treatment center.

How Does Antabuse Work?

As mentioned, when you take Antabuse, it prevents your body from properly breaking down alcohol. Normally, after you drink, your body processes the alcohol in stages. Disulfiram specifically blocks the process of breaking down acetaldehyde.

When this substance builds up in your body, unpleasant symptoms kick in quickly. Even small amounts of alcohol can trigger:

  • Intense nausea
  • Vomiting
  • Flushing
  • Headaches
  • Racing heartbeat

The effects are so uncomfortable they make drinking alcohol a highly unpleasant experience, so it’s a deterrent to help people avoid alcohol while focusing on recovery.

Antabuse isn’t a magic fix, but it does create a physical barrier that makes it easier to stick to sobriety. When combined with a broader treatment plan, it can be a helpful part of long-continuing recovery.

How Is Antabuse Taken?

When it comes to taking Antabuse, it’s critical to follow the prescribed amount and administration guidelines carefully.

Typically, Antabuse is taken as a once-daily pill, often in the morning. The precise dose may vary depending on your doctor’s recommendations, but the goal is to keep a consistent level of medicine in your system to prevent any alcohol consumption from slipping through without triggering symptoms.

Most treatment plans involving Antabuse include regular medical supervision to monitor how your body responds to the medication and to make sure there aren’t complications. In most cases, Antabuse is used along with therapy and other support systems to create a comprehensive recovery approach.

Antabuse should only be taken at a minimum of 12 hours after the last consumption of alcohol.

Skipping doses or stopping Antabuse without talking with your doctor can reduce the effectiveness and increase the risk of relapse.

Who Should Take Antabuse?

Antabuse is usually recommended for individuals committed to quitting alcohol and who are looking for additional support to stay sober. Ideal candidates for Antabuse therapy are those who have already gone through detox, aren’t physically dependent on alcohol anymore, and want to avoid relapse.

It’s a good option for people motivated to maintain their sobriety but may benefit from a deterrent to help them resist the urge to drink.

However, Antabuse isn’t for everyone. People with certain medical conditions like liver problems or severe heart disease may have to avoid it. It’s also important anyone who takes Antabuse fully understands the risks since drinking any amount of alcohol while on it can lead to serious reactions.

Benefits of Using Antabuse in Alcohol Addiction Treatment

Antabuse offers a unique way to support long-term sobriety, serving as a strong deterrent to drinking. For many people in recovery, knowing that consuming alcohol will lead to very unpleasant effects can be enough to help them avoid the temptation to drink.

The barrier reinforces the mental and emotional work being done in therapy, helping people stay on track when cravings hit.

A key role of disulfiram is relapse prevention.

Even after detox and initial treatment, the risk of relapse is very real, especially during stressful times or social situations where alcohol is present. By causing immediate negative symptoms, Antabuse is an extra level of defense that can give you time to think twice before making a decision that could lead to relapse.

Side Effects and Risks

As is true with any medication, disulfiram can come with its share of side effects. Some of the common side effects are headaches, drowsiness and mild skin rashes. These symptoms are generally mild and start going away as your body adjusts to the medication.

One of the biggest risks is what happens if you drink alcohol while taking it. The severe reaction can include not only nausea and vomiting but also chest pain and difficulty breathing. In more serious situations, especially if someone ingests substantial quantities of alcohol, it can lead to more dangerous reactions like irregular heartbeat, seizures or even death. That’s why it’s crucial to avoid alcohol in all forms.

Not everyone is a good candidate for this therapy, so you should talk to your doctor about your full medical history before starting it.

If you’re wondering what is Antabuse and whether it’s a safe option for you, it’s best to consult with a professional who can lead you through the decision-making process.

At Mandala Healing Center, we ensure that all of our clients receive personalized care and that any treatment plan, including Antabuse, is safe and effective for their specific needs.

References:

  1. National Institute of Health (NIH): Disulfiram
  2. NIH: Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis
  3. JAMA Network: Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-Dependent Outpatients
  4. Wiley Online Library: Does disulfiram have a role in alcoholism treatment today?